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Brotman曾报告丙谷氨酰转移酶(GGTP)可作为非甲非乙肝炎病毒携带状态检测的可能的替代指标.本文作者基于几组病人的临床研究.对此持否定态度.(1)37例治愈并随访2-15年的白血病或肿瘤患儿,有输血史,随后sGPT异常并有肝组织感染性损害,排除了HBV、CMV或EBV感染,确诊为非甲非乙型慢性肝炎.GGTP平均值35.32(5-95)IU/L,但GGTP升高者仅3例;(2)72例HBsAg携带者中35例HDV抗体阳性,随访4.7-14年,GGTP平均39.91(8-106)IU/L,但有6例GGTP升高;(3)该72例HBsAg携带者中37例HDV抗体阴性,随访5-14年,GGTP平均44.2(1-613)IU/L,有2例GGTP升高;(4)作者还偶然发现150例青少年患儿,在停止治疗后随访中有5例GGTP异常,但无肝损和胆汁郁滞情况;(5)10例多次(每月)输血的地
Brotman reported that GGTP may serve as a potential surrogate marker for the detection of non-A, non-Hepatitis B virus carrier status, and the authors disagree on the clinical studies of several groups of patients (1) 37 Patients with leukemia or tumor who were cured and followed up for 2 to 15 years had a history of blood transfusion, subsequent sGPT abnormalities and liver tissue damage, and excluded HBV, CMV or EBV infection and were diagnosed as non-A, B type hepatitis 35.32 (5-95) IU / L, but only three patients with elevated GGTP; (2) 35 out of 72 HBsAg carriers were positive for HDV antibody. The average GGTP was 39.91 (8-106) IU / L, but there were 6 cases of GGTP increased; (3) Among the 72 cases of HBsAg carriers, 37 cases of HDV antibodies were negative, followed up for 5-14 years, the average GGTP was 44.2 (1-613) IU / L, High; (4) The authors also occasionally found 150 cases of adolescent children with GGTP abnormalities, but no liver damage and cholestasis in follow-up after stopping treatment; (5) 10 cases of multiple (monthly) transfusion Ground