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1.本文报告了汉防己甲素(以下简称汉甲素)对大鼠矽肺的预防和病后疗效观察。结果表明治疗组的全肺千重及胶原含量显著低于对照组,T/C值约0.5左右,病理检查预防治疗组的病变主要由大细胞组成,未见纤维性结节;病后治疗组矽结节数量及融合病灶明显减少,结节中胶原纤维排列松散和退变。2,汉甲素最小有效量为每周30mg/kg,最佳剂量为每周90～120mg/kg。一般每周口服三次。3,汉甲素对大鼠肝、肾有一定毒性,每周120mg/kg治疗5～6个月,可引起肝、肾细胞的坏死。
1. This article reports the prevention of tetrandrine (hereinafter referred to as hantai) on silicosis in rats and the observation of the curative effect. The results showed that the treatment group, the whole lung thousand and collagen content was significantly lower than the control group, T / C value of about 0.5, pathological examination prevention group lesions mainly composed of large cells, no fibrous nodules; after treatment group The number of nodules and fusion lesions significantly reduced the nodules in the arrangement of loose and degenerative collagen fibers. 2, the minimum effective amount of norepinephrine 30mg / kg weekly, the optimal dose of 90 ~ 120mg / kg per week. Generally oral three times a week. 3, hantavirus on rat liver and kidney have some toxicity, 120mg / kg weekly treatment of 5 to 6 months, can cause liver and kidney cell necrosis.