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目的 探讨恩丹西酮在预防化疗呕吐的临床应用效果。方法 5 3例以阿霉素或顺铂为主的化疗患者随机分为恩丹西酮组和胃复安组 ,观察 1～ 5天呕吐控制率。结果 恩丹西酮控制率第 1天84 9% ,第 2天 76 4% ,第 3天 74 5 % ,第 4天 78 3% ,第 5天 89 6 % ,胃复安组第 1天 5 4 5 % ,第 2天5 8 6 % ,第 3天 6 1 6 % ,第 4天 72 7% ,第 5天 84 8%。第 1、2、3天相比有显著性差异。结论 恩丹西酮在控制以阿霉素或顺铂为主的化疗中 ,止吐控制率优于胃复安。
Objective To investigate the clinical effect of ondansetron in the prevention of chemotherapy vomiting. METHODS: Fifty-three patients with adriamycin or cisplatin-based chemotherapy were randomly divided into the ondansetron group and the metoclopramide group. The vomiting control rate was observed for 1 to 5 days. Results The rate of ondansetron control was 84 9% on the first day, 76 4% on the second day, 74 5% on the third day, 78 3% on the fourth day, 89.6% on the fifth day, and the first day of the metoclopramide group5 45%, 5 8 6 % on the second day, 6 1 6 % on the 3rd day, 72 7% on the 4th day, and 84 8% on the 5th day. There was a significant difference on days 1, 2 and 3 compared. Conclusion Ondansetron is superior to metoclopramide in the control of doxorubicin or cisplatin-based chemotherapy.