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目的:研究辅料微晶纤维素(microcrystalline cellulose,MCC)与聚乙二醇6000(polyethylene glycol 6000,PEG6000)对三叶片药粉的压缩特性的影响。方法:分别选择MCC,PEG6000以不同比例与三叶片药粉混合均匀,测得粉体真密度,在不同压力下压制成片后,记录每片所需压力,并测量每片的体积、片重及硬度,进而得到相应的Ryshkewitch-Duckworth方程和Heckel方程参数,表征片剂的压缩特性。结果:以Ryshkewitch-Duckworth方程分析可得,压缩到同等程度,MCC加入量越大,片剂的抗张强度越大,而PEG6000无此作用。若以Heckel方程比较不同粉末所需的压片压力,含有PEG6000的药粉所需的压力远小于加入MCC的药粉,且PEG6000的屈服应力小于MCC。结论:2种辅料对药粉压缩特性的影响属于不同方面的作用,MCC提高压缩特性中的可压片性,PEG6000则可改善其中的可压缩性,显著减小压片压力,为筛选稳定处方提供科学参考。
Objective: To study the effects of microcrystalline cellulose (MCC) and polyethylene glycol 6000 (PEG6000) on the compression properties of trilobal powder. Methods: MCC and PEG6000 were respectively mixed in different proportions with three-leaf powder. The true density of the powder was measured. After the tablets were compressed at different pressures, the required pressure of each tablet was recorded. The volume, Hardness, and then get the corresponding Ryshkewitch-Duckworth equation and Heckel equation parameters, characterize the compression characteristics of tablets. Results: According to the Ryshkewitch-Duckworth equation, the compression to the same degree, the larger the amount of MCC, the greater the tensile strength of the tablets, while the PEG6000 did not. If the Heckel equation is used to compare the tableting pressures required for different powders, the pressure required for the PEG 6000-containing powder is much less than that for the MCC-added powder, and the yield stress for PEG 6000 is less than for MCC. CONCLUSION: The effects of the two excipients on the compressibility of the powder belong to different aspects. The MCC improves the compressibility of the compressive properties and PEG6000 can improve the compressibility, significantly reduce the tablet pressure and provide a stable prescription for screening Scientific reference.