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目的 探讨过敏性紫癜患儿应用肝素钙预防肾损害的有效性、可行性。方法 将 5 9例过敏性紫癜患儿随机分成肝素钙治疗组和对照治疗组 ,另设非HSP对照组 2 0例 ,追踪监测尿 β2 微球蛋白 (β2 M )、尿微量白蛋白 (Alb)。结果 两组在治疗前尿 β2 M和尿Alb差异无显著性 (P >0 0 5 ) ,治疗后 3个月、6个月肝素钙治疗组尿 β2 M和尿Alb低于对照治疗组 ,差异有显著意义 (P <0 0 1)。肝素钙治疗组 6个月后尿Alb与非HSP组相比差异无显著性 (P >0 0 5 )。结论 肝素钙可有效地预防过敏性紫癜肾损害 ,且安全可靠
Objective To investigate the effectiveness and feasibility of heparin calcium in prevention of renal damage in children with Henoch-Schonlein purpura. Methods Fifty-nine children with Henoch-Schonlein purpura were randomly divided into heparin calcium treatment group and control group. Another 20 non-HSP control subjects were enrolled in this study. The urinary β2 microglobulin (β2 M), urinary albumin (Alb) . Results There was no significant difference in urinary β2 M and urinary Alb between the two groups before treatment (P> 0.05). Urinary β2 M and urinary Alb in heparin calcium group were lower than those in control group at 3 and 6 months after treatment Significant (P <0.01). There was no significant difference in urine Alb between non-HSP group and 6-month heparin calcium treatment group (P> 0.05). Conclusion Heparin calcium can effectively prevent renal damage of allergic purpura and is safe and reliable