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胰岛素抵抗和脂质代谢异常是2型糖尿病发生的主要原因.胰岛素和炎症信号通路在胰岛素抵抗和脂肪积累中起重要作用.接头蛋白可以介导胰岛素受体或炎症细胞因子受体来的信号到下游分子,因此接头蛋白会调节肥胖和2型糖尿病中的胰岛素抵抗和脂质代谢异常.本文总结和讨论了接头蛋白在胰岛素抵抗和脂质代谢平衡中的最新进展.
Insulin resistance and dyslipidemia are the major causes of type 2 diabetes.Insulin and inflammatory signaling pathways play an important role in insulin resistance and adipose accumulation.The adapter proteins can mediate signals from insulin receptors or inflammatory cytokine receptors to Downstream molecules, linker proteins regulate insulin resistance and lipid metabolism in obesity and type 2 diabetes.This paper summarizes and discusses the recent advances in adapter proteins in the balance of insulin resistance and lipid metabolism.