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1940—1960年间,肝肾综合征(Hepa-torenal Syndrome,HRS)几乎包括了可影响肝肾二个器官的所有疾患,分三种情况:一是肝肾因同一病因而致病,如钩端螺旋体病、华佛氏症候群和四氯化碳中毒等;其次是肾病基础上继发肝损害,如肾功能衰竭合并脂肪肝等;三是严重肝胆疾病基础上继发肾功能障碍。第三种情况在临床上最多见、最重要,广义的肝肾综合征就是指的这一种。
Between 1940 and 1960, Hepato-Renal Syndrome (HRS) included almost all of the disorders that affected both organs of the liver and kidney. There were three cases: First, the liver and kidney were caused by the same cause, Spirochete disease, Warblers syndrome and carbon tetrachloride poisoning; followed by nephropathy secondary to liver damage, such as renal failure with fatty liver; third is the serious liver and gallbladder disease on the basis of secondary renal dysfunction. The third case is clinically the most common, most important, generalized hepatorenal syndrome refers to this one.