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目的通过测定反复呼吸道感染(recurrent respiratory tract infections,RRTIs)幼儿的血清25-(OH)D3水平及分布特点,探讨血25-(OH)D3水平与幼儿期RRTIs的关系,为临床治疗和预防提供参考依据。方法选取2014年6月—2015年6月本院儿科门诊收治的RRTIs患儿80例作为RRTIs组,选取同期到我院儿童保健门诊体检的健康幼儿80例作为对照组。受检者均抽取静脉血2 ml检测并比较两组血清25-(OH)D3水平。同时统计并比较两组维生素D水平,并回顾性调查研究对象维生素D制剂补充情况及平均户外活动时间。计量资料采用t检验,计数资料采用χ~2检验,等级资料采用秩和检验,P<0.05为差异有统计学意义。结果 RRTIs组血清25-(OH)D3水平为(25.7±17.3)nmol/L,显著低于对照组的(50.9±15.2)nmol/L,差异有统计学意义(P<0.05)。RRTIs组25-(OH)D3缺乏率及正常率分别为35.00%、18.75%,对照组分别为12.50%、51.25%,两组比较差异均有统计学意义(均P<0.05)。RRTIs组平均户外活动时间>2 h/d率为43.75%,显著低于对照组的61.25%,差异有统计学意义(P<0.05)。结论 RRTIs患儿血清25-(OH)D3水平显著低于健康幼儿,提示低水平25-(OH)D3可能增加RRTIs发病风险,及时补充维生素D制剂、适当户外活动有助于预防RRTIs。
Objective To investigate the relationship between serum 25- (OH) D3 levels and RRTIs in early childhood by determining serum 25- (OH) D3 levels and distribution in children with recurrent respiratory tract infections (RRTIs), and to provide clinical treatment and prevention Reference. Methods Eighty children with RRTIs admitted to pediatric clinic in our hospital from June 2014 to June 2015 were selected as RRTIs group, and 80 healthy children from the same period to our hospital child health clinic were selected as control group. Subjects were drawn venous blood 2 ml detection and comparison of serum 25- (OH) D3 levels. Statistics and comparison of the two groups of vitamin D levels, and retrospective study of vitamin D preparations to supplement the situation and the average outdoor activity time. Measurement data using t test, count data using χ ~ 2 test, rank data using rank sum test, P <0.05 for the difference was statistically significant. Results The level of 25- (OH) D3 in RRTIs group was (25.7 ± 17.3) nmol / L, which was significantly lower than that in the control group (50.9 ± 15.2) nmol / L, the difference was statistically significant (P <0.05). RRTIs group 25- (OH) D3 lack of rate and normal rate were 35.00%, 18.75%, respectively, the control group were 12.50%, 51.25%, the difference between the two groups were statistically significant (P <0.05). RRTIs group average outdoor activity time> 2 h / d rate was 43.75%, significantly lower than the control group of 61.25%, the difference was statistically significant (P <0.05). Conclusions Serum 25- (OH) D3 in children with RRTIs is significantly lower than that in healthy children, suggesting that low levels of 25- (OH) D3 may increase the risk of RRTIs and provide timely vitamin D supplementation. Appropriate outdoor activities may help prevent RRTIs.