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细胞外基质蛋白-1(ECM1)是一种分泌型糖蛋白,可刺激内皮细胞增殖,促进血管形成。在胃癌组织和其他恶性上皮肿瘤中高表达,与恶性肿瘤的浸润和转移相关。基质金属蛋白酶9(MMP-9)可降解基底膜和细胞外基质,促进脉管形成而增强胃癌细胞的侵袭和转移能力。探讨ECM1与MMP-9在胃癌发生发展中的作用将有助于人们进一步认识肿瘤与其周围微环境相互作用的机制,为胃癌的早期诊断和治疗提供理论依据。
Extracellular matrix protein-1 (ECM1) is a secreted glycoprotein that stimulates endothelial cell proliferation and promotes angiogenesis. It is highly expressed in gastric cancer tissues and other malignant epithelial tumors, and is associated with the invasion and metastasis of malignant tumors. Matrix metalloproteinase 9 (MMP-9) can degrade the basement membrane and the extracellular matrix, promote vascularization and enhance the invasion and metastasis of gastric cancer cells. To explore the role of ECM1 and MMP-9 in the development of gastric cancer will help people to further understand the mechanism of interaction between tumor and its surrounding microenvironment and provide a theoretical basis for the early diagnosis and treatment of gastric cancer.