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目的 :了解HBsAg阴性的乙肝患者血清DNA及肝组织中HBsAgHBcAg的表达。方法 :对近四年 3 3例病因不明的慢性肝病患者及HBsAg自然转阴的 17例乙型肝炎患者的资料进行分析。结果 :3 3例HBsAg阴性的慢肝患者中 ,8例血清中可检测到HBVDNA ;2例HBVDNA阴性患者肝组织中可检测到HBsAgHBcAg。 17例HBsAg自然转阴的乙肝患者中 ,12例血清中可检测到HBVDNA阳性者共 2 0例 ,18例肝活检 ,肝组织中均可检测到HBsAg和 /或HBcAg。结论 :HBsAg阴性不能排除乙型肝炎病毒感染 ,HBsAg转阴并意味着病毒血症的清除和乙肝的痊愈 ,须进一步检测血清DNA及肝组织中的HBsAgHBcAg。
Objective: To understand the serum DNA of HBsAg-negative hepatitis B patients and the expression of HBsAg HBcAg in liver tissues. Methods: The data of 33 patients with chronic liver disease of unknown etiology and 17 patients with hepatitis B who spontaneous negative HBsAg were analyzed in the recent four years. Results: Of the 3 3 HBsAg-negative chronic liver disease patients, HBVDNA was detected in 8 serum samples and HBsAg HBcAg protein was detected in 2 HBV DNA negative samples. Of the 17 HBsAg-negative hepatitis B patients, 20 were positive for HBVDNA in 12 serum samples and 18 were liver biopsy samples. HBsAg and / or HBcAg were detected in all the liver tissues. Conclusion: Negative HBsAg can not rule out hepatitis B virus infection. HBsAg negative translates to viremia clearance and hepatitis B recovery. Serum DNA and HBsAg HBcAg in liver tissues should be further tested.