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甲胎蛋白（AFP）阳性胃癌（AFPGC）因其恶性度高、进展快、易转移、预后差等特点，逐渐在临床上受到重视，被认为是一种特殊类型的胃癌。目前AFPGC的治疗更多的是借鉴普通胃癌，但疗效逊于普通胃癌。故针对此类胃癌，探寻其临床病理特征，特别是分子生物学特征，将对该病的诊断及个体化治疗具有十分重要的意义。本文将对AFPGC的定义、临床特征、分子病理特征及治疗现状等方面的研究进展作一综述。“,”Alpha fetoprotein(AFP)-producing gastric cancer is featured with high malignancy, rapid progress, easy to trans-fer, poor prognosis and etc, drawing more attention than ever before. It is considered to be a special type of gastric cancer. Currently, treatment of AFP-positive gastric cancer follows AFP-negative gastric cancer, but the effect is not as good as the common AFP-negative gastric cancer. Therefore, it is very important to explore clinicopathological features of AFP-producing gastric cancer, especially molec-ular biological characteristics on the diagnosis and individualized treatment. This paper summarized the development of the definition of AFP-producing gastric cancer, clinical characteristics, molecular pathology features, treatment status and other aspects.