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目的:探讨血管内皮生长因子(VEGF)在支气管哮喘发病中的作用,以及诱导痰技术在哮喘气道炎症与气道重塑检测方面的应用价值。方法:利用ELISA法检测哮喘患者诱导痰中VEGF的浓度并检测各种炎症细胞的数量。结果:中重度哮喘患者与健康对照组相比痰中VEGF的水平有显著性差异(P(0.05)。嗜酸性粒细胞数与VEGF水平呈正相关。结论:诱导痰中嗜酸性粒细胞、血管内皮生长因子检测可用于评价支气管哮喘气道炎症与气道重塑。
Objective: To investigate the role of vascular endothelial growth factor (VEGF) in the pathogenesis of bronchial asthma and its application in the detection of airway inflammation and airway remodeling in asthma. Methods: The concentration of VEGF in induced sputum of asthmatic patients was detected by ELISA and the number of various inflammatory cells was detected. Results: There was a significant difference in sputum VEGF levels between moderate and severe asthmatic patients (P <0.05) .The number of eosinophils was positively correlated with VEGF level.Conclusion: The eosinophils and vascular endothelium Growth factor testing can be used to evaluate bronchial airway inflammation and airway remodeling.