论文部分内容阅读
近年来由于细胞动力学的阐明和化疗药物的进展,急性白血病的疗效极为显著,成人患者的完全缓解率可达60～80%,5年生存率迅速增加,尤其是小儿的急性淋巴细胞型白血病(以下简称急淋)从完全缓解率及生存的时间来看,甚至可以认为是能够治愈的疾患。与此相反慢性粒细胞型白血病(以下简称慢粒)过去50年来几乎无何进步。但从血液学的基本问题特别是自血细胞的增殖和分化的角度看也有许多新的观点,引起国内外学者的重视,先后曾召开过慢粒专题会议进行了深入的讨论。现就慢粒急性变、治疗和其他有关的几个问题介绍如下。
In recent years, due to the clarification of cell kinetics and the progress of chemotherapeutic drugs, the therapeutic effect of acute leukemia is extremely remarkable. The complete remission rate of adult patients can reach 60-80% and the 5-year survival rate increases rapidly, especially in children with acute lymphoblastic leukemia (Hereinafter referred to as acute shower) from the complete response rate and survival time point of view, can even be considered to be able to cure the disease. In contrast, chronic myeloid leukemia (hereinafter referred to as CML) almost no progress over the past 50 years. However, there are many new ideas from the perspective of hematology, especially from the perspective of proliferation and differentiation of blood cells, arousing the attention of scholars both at home and abroad, and have held in-depth discussions on the topic of slow-grain. Acute acute changes now, treatment and other related issues are described below.