巴西某地区献血者中乳糜泻的患病率与人口统计学特征

• 作 者: Melo S.B.C. Fernandes M.I.M. Peres L.C. L.C.Galvo 张婷
• 机 构: Department of Pediatrics Faculty of Medicine of Ribeiro Preto,University of So Paulo,Av.Bandeirant
• 出 处: 世界核心医学期刊文摘(胃肠病学分册)
• 发表日期: 2006年12期
• 关键词: 乳糜泻 统计学特征 肌内膜 转谷氨酰胺酶 消化道肿瘤 抗体检测 活组织检查 抗体阴性 临床评估 空肠

Celiac disease(CD) is an underdiagnosed disease occurring in different clinical forms.This study aimed to determine the prevalence of CD among blood donors from Ribeir o Preto,Brazil,and to study some demographic characteristics of celiac patients.Blood samples from 3000 blood donors were tested for the presence of tissue transglutaminase antibody and positive samples were tested for endomysial antibody.Donors positive to both tests were referred for clinical evaluation and for a jejunal biopsy.Twenty-four samples were moderately/strongly positive for transglutaminase,with 9 of them being endomysial negative and 15 positive.Of the 13 biopsies obtained from 12 females and 1 male,1 was classified as Marsh grade IV,4 as grade III,2 as grade II,4 as grade I,and 2 as grade 0.Estimated prevalence was therefore 1∶ 273(0.33% ;95% CI,0.127 to 0.539) .The 1∶ 273 estimated prevalence of CD detected indicates that the disease is not rare in Brazil.The frequency was higher among females and among individuals of European descent,with a significantly higher frequency for a family history of digestive tract cancer or epilepsy.

Celiac disease (CD) is an underdiagnosed disease occurring in different clinical forms. This study aimed to determine the prevalence of CD among blood donors from Ribeir o Preto, Brazil, and to study some demographic characteristics of celiac patients. Blood samples from 3000 blood donors were tested for the presence of tissue transglutaminase antibody and positive samples were for endomysial antibody. Donors positive to both tests were referred for clinical evaluation and for a jejunal biopsy.Twenty-four samples were moderately / strongly positive for transglutaminase, with 9 of They were endomysial negative and 15 positive. Of the 13 biopsies obtained from 12 females and 1 male, 1 was classified as Marsh grade IV, 4 as grade III, 2 as grade II, 4 as grade I, and 2 as grade 0. Estimated prevalence was caused 1:273 (0.33%; 95% CI, 0.127 to 0.539). The 1: 273 estimated prevalence of CD detected indicates that the disease is not rare in Brazil. The frequency was higher among females and among individuals of European descent, with a significantly higher frequency for a family history of digestive tract cancer or epilepsy.