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目的核素门控心肌灌注显像(G-MPI)评估高血压前期(P-HTN)患者亚临床心脏靶器官损害,为药物干预提供依据。方法选取P-HTN患者40例,同时选取健康者40例作为对照。测定血脂、血糖(FPG)、血胰岛素,另外进行G-MPI,获得总负荷评分(SSS)、总静息评分(SRS)、总差值(SDS),左室射血分数(LVEF)、收缩末期容积(ESV)、舒张末期容积(EDV)、高峰射血速率(PER)、高峰充盈速率(PFR)、高峰充盈时间(TPFR)等参数。结果 2组年龄、性别、体重指数、血脂、FPG、血胰岛素差异无统计学意义(P>0.05);疾病组较对照组SSS及SDS明显增高,差异有统计学意义(P<0.01)。2组LVEF、ESV、EDV差异无统计学意义(P>0.05),而疾病组PFR明显降低,TPFR明显升高,差异有统计学意义(P<0.01)。结论 G-MPI在评估P-HTN患者亚临床心脏靶器官损害中起重要作用,具有重要意义。
Objective To evaluate the subclinical cardiac target organ damage in patients with prehypertensive (P-HTN) patients by G-MPI and provide the basis for drug intervention. Methods Forty patients with P-HTN were selected, and 40 healthy controls were selected as control. Blood glucose, blood glucose (FPG) and blood insulin were measured, G-MPI was performed separately, total load score (SSS), total resting score (SRS), total difference (SDS), left ventricular ejection fraction (LVEF) (ESV), end-diastolic volume (EDV), peak ejection rate (PER), peak filling rate (PFR), peak filling time (TPFR) and other parameters. Results There were no significant differences in age, sex, body mass index, blood lipids, FPG and blood insulin between the two groups (P> 0.05). The SSS and SDS in the disease group were significantly higher than those in the control group (P <0.01). There was no significant difference in LVEF, ESV and EDV between the two groups (P> 0.05), while the PFR in the disease group was significantly lower and TPFR was significantly higher (P <0.01). Conclusion G-MPI plays an important role in assessing subclinical cardiac target organ damage in patients with P-HTN.