A total synthesis of mycalisine A

• 作 者: Yan-Hui Dou Hai-Xin Ding Ru-Chun Yang Wei Li Qiang Xiao
• 机 构: Jiangxi Key Laboratory of Organic Chemistry,Jiangxi Science & Technology Normal University,
• 出 处: Chinese Chemical Letters
• 发表日期: 2013年05期
• 关键词: Naturally occurring nucleoside Total synthesis Vorbüggen glycosylation Mycalisin

In this paper,we report a total synthesis of a naturally occurring pyrrolo[2,3-d]pyrimidine nucleoside, mycalisine A.Our synthetic strategy uses D-xylose as the starting material and Vorbr(u|¨)ggen glycosylation as the key step.Mycalisine A was synthesized in 11 steps with a 15%overall yield.

In this paper, we report a total synthesis of a naturally occurring pyrrolo [2,3-d] pyrimidine nucleoside, mycalisine A. Our synthetic strategy uses D-xylose as the starting material and Vorbr (u |) ggen glycosylation as the key step. Mycalisine A was synthesized in 11 steps with a 15% overall yield.