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甲氰米胍(Cimetidine)能作用于肝脏微粒体酶,影某些药物在肝内灭活,以致药物在体内聚积,引起毒性反应,如甲氰米胍能使安定和华法令在体内积聚,引起一定的毒性作用。本文报告一例(15岁,女孩)在使用甲氰米胍后引起茶碱在体内积聚,并有可能达到中毒水平。患儿因慢性支气管哮喘每日服用茶碱11mg/Kg体重,血清浓度峰值为13.0ug/ml,两周后因胃肠道不适加用甲氰米胍后,血清茶碱浓度峰值达36.7ug/ml。停
Cimetidine acts on liver microsomal enzymes and inactivates certain drugs in the liver, causing the drug to accumulate in the body and cause toxic reactions such as cetanide, which causes diazepam and warfarin to accumulate in the body, Caused some toxic effects. One case (15 years old, girl) reported in this article caused the accumulation of theophylline in the body after the use of cidcaguanide and may reach the level of poisoning. Children with chronic bronchial asthma daily theophylline 11mg / Kg body weight, the peak serum concentration of 13.0ug / ml, two weeks later due to gastrointestinal discomfort with caimannan, serum peak theophylline concentration of 36.7ug / ml. stop