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液态芯片(liquid chip)是近年来新出现的一种临床应用型生物芯片,是以分类编码微球作为反应及信号检测载体,在液相反应体系中实现蛋白质、核酸等多种生物大分子的同步检测。既保持了生物芯片高通量的特性,又具有高灵敏度、高准确度、高精密度和线性测定范围宽及易操作等特点,在临床实验诊断领域具有广阔的应用前景。现就其基本原理、检测、特点在各临床诊断方面的应用作一综述。
Liquid chip (liquid chip) is a newly emerging clinical application of biochips in recent years, is based on the classification of encoded microspheres as a reaction and signal detection vector in the liquid reaction system to achieve a variety of biological macromolecules such as proteins, nucleic acids Synchronous detection. It not only maintains the characteristics of high-throughput biochip, but also has the characteristics of high sensitivity, high accuracy, high precision, wide linear range and easy operation. It has broad application prospects in the field of clinical laboratory diagnosis. Now on its basic principles, testing, features in the clinical diagnosis of each make a review.