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通过检测大鼠腹腔巨噬细胞（Ｍ）胞浆游离钙离子浓度（［Ｃａ２＋］ｉ）和４５Ｃａ内流与外排研究了不同浓度白芍总甙（ＴＧＰ）对ＭＣａ２＋跨膜转运的影响．结果表明，胞外有Ｃａ２＋时，ＴＧＰ（２．５－２０ｍｇＬ－１）对亚适浓度卡西霉素（０．１μｍｏｌＬ－１），脂多糖（ＬＰＳ，５ｍｇＬ－１）和甲酰三肽（ｆＭＬＰ，１μｍｏｌＬ－１）升高Ｍ的［Ｃａ２＋］ｉ具有明显的增强作用；而胞外无Ｃａ２＋时，ＴＧＰ对ＬＰＳ或ｆＭＬＰ刺激胞内钙池释放Ｃａ２＋引起［Ｃａ２＋］ｉ升高的作用无明显影响；ＴＧＰ可使卡西霉素刺激Ｍ的４５Ｃａ内流明显增加，同时较高浓度（１０－４０ｍｇＬ－１）亦浓度依赖性促进４５Ｃａ外排．这些结果提示，ＴＧＰ有促进胞外钙内流作用，较高浓度ＴＧＰ可促进胞内钙外排，从而降低［Ｃａ２＋］ｉ．
The effects of different concentrations of total glucosides of paeony on the migration of MCa2 + transmembrane were studied by measuring the intracellular free calcium concentration ([Ca2 +] i) and the 45Ca influx and efflux in rat peritoneal macrophages (M) influences. The results showed that TGP (2.5-20 mg L-1) had no effect on Ca2 +, Ca2 +, Ca2 +, Ca2 + The effect of TGP on [Ca2 +] i release from Ca2 + -induced intracellular Ca2 + -increased by LPS or fMLP in vitro without Ca2 + TGP significantly increased 45Ca Ca2 + influx in M and higher concentration (10-40mgL-1) promoted Ca2 + efflux in a dose-dependent manner. These results suggest that TGP promotes extracellular calcium influx and that higher concentrations of TGP promote intracellular calcium efflux and thereby reduce [Ca2 +] i.