PARK1 gene mutation of autosomal dominant Parkinson＇s disease family

• 作 者: Ligang Jiang Qiuhui Chen Ying
• 机 构: DepartmentofNeurology,DepartmentofNeurology,BeihuaUniversity
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2011年5期
• 关键词: 帕金森氏症 基因突变 显性遗传 常染色体 致病基因 突变位点 帕金森病 PCR技术 Parkinson＇s disease family genetic PAR
• 基金项目: Supported by： a Foundation of Science and Technology Department of Jilin Province, No. 200905152

Studies have shown that PARK1 gene is associated with the autosomal dominant inheritance of Parkinson’s disease. PARK1 gene contains two mutation sites, namely Ala30Pro and Ala53Thr, which are located on exons 3 and 4, respectively. However, the genetic l