论文部分内容阅读
目的:观察稳心颗粒联合美托洛尔片治疗冠心病伴心律失常的临床疗效。方法:回顾性分析72例冠心病伴心律失常患者的临床资料,对照组36例服用阿司匹林片、硝酸甘油片和美托洛尔片治疗,观察组36例服用稳心颗粒与美托洛尔片治疗,2组均治疗4周。比较2组患者治疗前、后中医证候积分变化及心电图变化情况,统计2组的临床疗效及不良反应。结果:观察组总有效率为94.4%,高于对照组的75.0%,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分均较治疗前下降,观察组积分值低于对照组,差异均有统计学意义(P<0.01)。2组PR间期均较治疗前缩短,而QRS波时限及QTc间期均较治疗前延长,观察组缩短或延长程度均优于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论:应用稳心颗粒联合美托洛尔片治疗冠心病伴心律失常疗效显著且安全。
Objective: To observe the clinical effect of Wenxin granule combined with metoprolol tablets in treatment of coronary heart disease with arrhythmia. Methods: The clinical data of 72 patients with coronary heart disease and arrhythmia were retrospectively analyzed. In the control group, 36 patients were treated with aspirin tablets, nitroglycerin tablets and metoprolol tablets, and 36 patients in the observation group were treated with Wenxin tablets and metoprolol tablets , Two groups were treated for 4 weeks. The changes of TCM syndrome scores and ECG before and after treatment were compared between the two groups, and the clinical curative effect and adverse reactions of the two groups were statistically analyzed. Results: The total effective rate in the observation group was 94.4%, which was higher than that in the control group (75.0%), the difference was statistically significant (P <0.05). After treatment, the scores of TCM syndromes in two groups decreased compared with those before treatment, and the scores in observation group were lower than those in control group (P <0.01). The PR interval in both groups was shorter than before treatment, while the QRS wave duration and QTc interval were longer than those before treatment. The shortening or prolongation of the observation group was better than that of the control group (P <0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P <0.05). Conclusion: The application of Wenshen granules combined with metoprolol tablets in the treatment of coronary heart disease with arrhythmia significant and safe.