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目的:探讨慢性持续期支气管哮喘患者痰液中白细胞介素-4(IL-4)水平与其临床基线评估的相关性。方法:分别对慢性持续期支气管哮喘患者轻度16例、中度14例、重度18例进行临床基线评估,主要是肺功能检测及哮喘症状控制评分;并同时采用酶联免疫吸附试验(ELISA)法检测其诱导痰液中IL-4水平。结果:慢性持续期支气管哮喘患者痰液中IL-4水平与肺通气功能指标FEV1%呈负相关,与哮喘发作程度临床症状评分相一致。结论:慢性持续期支气管哮喘患者痰液中IL-4水平与其发作程度有关,能作为哮喘评估的一项指标。
Objective: To investigate the correlation between the level of interleukin-4 (IL-4) in sputum and the clinical baseline assessment in patients with chronic persistent asthma. Methods: Clinical baseline assessment was performed in 16 patients with mild persistent bronchial asthma, 14 patients in moderate and 18 severe cases, respectively. The main clinical features were pulmonary function test and asthma symptom control score. Meanwhile, the enzyme linked immunosorbent assay (ELISA) Method to detect IL-4 level in induced sputum. Results: IL-4 level in sputum of patients with chronic persistent asthma was negatively correlated with FEV1% of pulmonary ventilation function, which was consistent with clinical symptom score of asthma attack. Conclusion: The level of IL-4 in sputum of patients with chronic persistent asthma is related to the severity of asthma and can be used as an indicator of asthma evaluation.