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探讨胰岛素样生长因子Ⅰ (IGF -Ⅰ )、胰岛素样生长因子结合蛋白 - 3(IGFBP - 3)与肝硬化患者营养状况的关系 ,分析IGF -Ⅰ和IGFBP - 3对肝硬化患者营养状况的影响。肝硬化患者 6 5例 ,按Child -pugh分级法将其分为A(17例 ) ,B(2 0例 )和C(2 8例 )三组 ,对照组 30例 ,应用放射免疫法检测空腹IGF -Ⅰ和IGFBP - 3,并测定患者的上臂围、三头肌皮脂厚度、上臂肌围等营养状况指标。肝硬化患者血清IGF -Ⅰ和IGFBP - 3水平下降(10 0 49± 38 11)ng/ml对 (35 2 5 5± 15 3 6 1)ng/ml,(P <0 0 0 1) ;(4 5 0 2± 16 2 1)nmol/L对 (114 5 0± 2 7 0 9)nmol/L ,(P <0 0 0 1) ,IGF -Ⅰ、IGFBP - 3与营养状况呈明显正相关 (P <0 0 0 1)。IGF -Ⅰ和IGFBP - 3可作为反映肝硬化患者营养状况的指标
To investigate the relationship between insulin-like growth factor-Ⅰ (IGF-Ⅰ), insulin-like growth factor binding protein-3 (IGFBP - 3) and nutritional status in cirrhotic patients and to analyze the influence of IGF- . Sixty-five patients with cirrhosis were divided into three groups according to Child-Pugh classification: A (17 cases), B (20 cases) and C (28 cases), and 30 cases in control group. Radioimmunoassay was used to detect fasting IGF - I and IGFBP - 3, and measured the upper arm circumference, triceps sebum thickness, upper arm muscle circumference and other nutritional status indicators. Serum levels of IGF-I and IGFBP-3 in patients with cirrhosis decreased (10 49 ± 38 11) ng / ml to (35 2 55 ± 15 361) ng / ml, (P 0 01 0) There was a significant positive correlation between IGF - Ⅰ, IGFBP - 3 and nutrition status (P <0.01), nmol / L (11450 ± 2707 nmol / L, (P <0 0 0 1). IGF-I and IGFBP-3 can be used as indicators to reflect the nutritional status of patients with cirrhosis