Molecular Mechanisms Contributing to Resistance to Tyrosine Kinase-Targeted Therapy for Non-Small Ce

• 作 者: Fariz Nurwidya Akiko Murakami
• 机 构: DepartmentofRespiratoryMedicine
• 出 处: 临床肿瘤与癌症研究：英文版
• 发表日期: 2012年1期
• 关键词: 非小细胞肺癌 受体酪氨酸激酶 靶向治疗 分子机制 表皮生长因子受体 临床试验 分子生物学 EGFR carcinoma non-small-cell lung

<正>One of the most important pathways in non-small cell lung cancer(NSCLC) is the epidermal growth factor receptor(EGFR) pathway. This pathway affects several crucial processes in tumor development and progression,including tumor cell proliferation,