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目的 探讨尿型纤溶酶受体 (UPAR)和血管内皮生长因子 (VEGF)在肝细胞肝癌 (HCC)的表达与其病理学特性和肿瘤浸润转移的关系 .方法 采用抗受体抗体 SABC免疫组织化学染色检测 79例肝细胞肝癌标本中 UPAR表达 ,以常规 SABC免疫组化方法检测 VEGF的表达 .结果 在 79例 HCC中 ,UPAR的表达阳性率为 5 1.9% (41/ 79) ,VEGF的表达阳性率为 4 6 .8%(37/ 79) ,二者表达与肝癌大小、分化程度无关 ,但与肿瘤的转移显著相关 .结论 U PAR和 VEGF的表达可作为 HCC的侵袭表型 ,可作为估计预后的指标 ,肝细胞肝癌中 VEGF的表达与 UPAR表达具有较高的相关性
Objective To investigate the relationship between the expression of urinary plasminogen activator receptor (UPAR) and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC) and their pathological features and tumor invasion and metastasis.Methods The anti-receptor antibody SABC immunohistochemistry The expression of UPAR in 79 samples of hepatocellular carcinoma was detected by immunohistochemical staining with SABC immunohistochemistry.Results The positive expression rate of UPAR was 51.9% (41/79) in 79 cases of HCC, the expression of VEGF was positive (37/79), the expression of which was not related to the size and differentiation of HCC, but was significantly correlated with tumor metastasis.Conclusion The expression of U PAR and VEGF can be used as the invasive phenotype of HCC and can be used as an estimate Prognostic indicators, the expression of VEGF in hepatocellular carcinoma has a higher correlation with the expression of UPAR