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目的探讨血小板在脑缺血损害中的作用及血小板颗粒膜蛋白（ＧＭＰ－１４０）的临床意义。方法对２６例急性脑梗塞患者发病后６ｈ内、２４ｈ、第３天、第７天、第１４天血浆内ＧＭＰ－１４０的水平进行了动态测定。结果发病后２周的血浆ＧＭＰ－１４０水平均高于正常对照组（Ｐ＜０．０５）。发病后６小时内即见血浆ＧＭＰ－１４０水平增高，至第３天达最高水平，以后逐渐降低。第３天ＧＭＰ－１４０水平与梗塞灶最大直径呈显著正相关（ｒ＝０．５６，Ｐ＜０．０１）。结论急性脑梗塞患者存在全身血小板持续激活状态，ＧＭＰ－１４０直接参与了脑梗塞的病理损伤过程，并可作为判断预后的指标
Objective To investigate the role of platelets in cerebral ischemia and the clinical significance of platelet granule membrane protein (GMP-140). Methods The levels of plasma GMP-140 in 26 patients with acute cerebral infarction within 6 hours, 24 hours, 3 days, 7 days and 14 days after onset were measured. Results The level of plasma GMP-140 in the two weeks after onset was higher than that in the normal control group (P <0.05). Within 6 hours after onset, the level of plasma GMP-140 increased, reaching the highest level on the third day and then gradually decreasing. On the third day, there was a significant positive correlation between GMP-140 level and the maximum diameter of infarction (r = 0.56, P <0.01). Conclusion There is a sustained platelet activation in patients with acute cerebral infarction. GMP-140 is directly involved in the pathological process of cerebral infarction and can be used as an indicator of prognosis