Relationship between urokinase-type plasminogen activator receptor and vascular endothelial growth f

• 作 者: Shu-Qiang Yue Yan-Ling YANG Jing-Shi Zhou Kai-Zong Li Ke-Feng Dou
• 机 构: Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 7100
• 出 处: 世界胃肠病学杂志（英文版）
• 发表日期: 2004年18期
• 关键词: gallbladder cancer growth factor expression pathological characteristics immunoh

AIM: To investigate the relationship of urokinase type plasminogen activator reoeptor (uPAR) and vascular endothelial growth factor (VEGF) expression with dinical and pathological characteristics of human gallbladder cancer.METHODS: uPAR and VEGF expressions in 68 gallbladder cancer tissues were detected with anti-receptor immunohistochemical stain.RESULTS: Expression rate of uPAR was 57.4% (39/68), and VEGF 51.5% (35/68) in gallbladder cancer tissues. Expression of both uPAR and VEGF was significantly related to metastasis, but not significantly correlated with differentiation stage and size of gallbladder cancer.CONCLUSION: Expression of uPAR and VEGF may be an invasive phenotype of gallbladder cancer and indicator for predicting prognoses, and uPAR expression is significantly correlated with the expression of VEGF.