Regulation of the mRNA half-life in breast cancer

• 作 者: Paola Griseri Gilles Pagè
• 机 构: UnitedOrthopedicCorporation,UniversityofNiceSophiaAntipolis
• 出 处: 世界临床肿瘤学杂志
• 发表日期: 2014年3期
• 关键词: mRNA stability BREAST cancer RNA BINDING PROTEINS MicroRNA ALTERNATIVE POLYADENY
• 基金项目: A fellowship from“Fondazione Umberto Veronesi”to Griseri P,the French National Institute of Cancer(INCA),the French Association for Cancer Research(ARC),the Fondation de France,the Conseil Gén

The control of the half-life of mRNA plays a central role in normal development and in disease progression.Several pathological conditions,such as breast cancer,correlate with deregulation of the half-life of mRNA encoding growth factors,oncogenes,cell cy