论文部分内容阅读
白血病患者常有发热,感染为其主要原因.而白血病患者易于感染则可能与免疫功能低下及粒细胞减少等因素有关.本文对白血病发热者54份标本进行了微生物学检查(包括需氧、厌氧及真菌培养),培养结果,阳性22份(阳性率40.74%).其中分离出葡萄球菌最为多见,其次为变形杆菌及真菌.关于白血病患者的免疫状态问题,各家意见不一.本文检测了正常人51例次及不同时期白血病患者45例次的E活性玫瑰花结率,结果以治疗前的白血病患者E活性玫瑰花结率为最低(12.%),与正常人有非常显著的差异.表明了白血病患者细胞免疫功能受损.本文用一些化疗剂在体外能使正常人E活性玫瑰花结率降低,说明化疗剂对E活性玫瑰花结的形成有抑制作用.动物实验也表明:连用三天氢化考的松后小白鼠腹腔巨噬细胞吞噬功能明显降低(吞噬百分率及吞噬指数分别为13.4%及0.18;对照组分别为42.4%及0.70)证实氢化考的松对巨噬细胞吞噬功能有显著的抑制作用.
Leukemia patients often have fever, the main reason for the infection, while the susceptibility of leukemia patients may be related to immune dysfunction and neutropenia and other factors.In this paper, 54 samples of leukemia fever were microbiological examination (including aerobic, Oxygen and fungi culture), the results of culture were positive 22 (positive rate 40.74%). Staphylococcus aureus was the most common, followed by Proteus and fungi.About the immune status of leukemia patients, different opinions. The results showed that the percentage of E-reactive rosette in the leukemia patients before treatment was the lowest (12.%), which was significantly higher than that in normal people Of the difference, indicating that cellular immune function in patients with leukemia impaired.In this paper, with some chemotherapeutic agents in vitro can make the normal human E-reactive rosette reduced, indicating that the chemotherapeutic agents on the formation of E-reactive rosettes inhibited animal experiments The results showed that phagocytosis of peritoneal macrophages in mice treated with three days hydrocortisone was significantly decreased (phagocytosis percentage and phagocytic index were 13.4% and 0.18 respectively; control group were 42.4% And 0.70) confirmed that hydrocortisone significantly inhibited macrophage phagocytosis.