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目的 了解中国大陆钉螺对氯硝柳胺的敏感性。 方法 运用分层随机抽样方法 ,兼顾我国钉螺孳生地类型 ,抽取了 10省 (市 )、33个县 37个点的钉螺 ,氯硝柳胺用脱氯自来水配成有效浓度为 1.0 0 0 0、 0 .5 0 0 0、0 .2 5 0 0、0 .12 5 0、0 .0 6 2 5、0 .0 313和 0 .0 15 7mg/L的药液 ,在 2 5℃室温下分别进行浸泡杀螺实验。 结果 1.0mg/L氯硝柳胺浸泡钉螺 2 4h死亡率达 10 0 % ,各点钉螺的LC50 为 0 .0 32 0～ 0 .16 89mg/L ,均值为 0 .0 92 0mg/L。 0 .5mg/L氯硝柳胺浸泡钉螺 48h死亡率达 10 0 % ,各地区钉螺的LC50 为 0 .0 2 99～ 0 .1114mg/L ,均值为 0 .0 6 2 7mg/L。不同点间钉螺对氯硝柳胺敏感性差异有显著性意义 (P <0 .0 1)。 结论 不同点间钉螺对氯硝柳胺敏感性存在差异 ,但 1.0mg/L氯硝柳胺可有效浸杀我国所有地区的钉螺。
Objective To understand the sensitivity of snail to niclosamide in mainland China. Methods The stratified random sampling method was used, taking into account the types of snail breeding places in our country, 37 snails of 10 provinces (municipalities) and 33 counties were selected for snail treatment. The niclosamide was dechlorinated tap water to form an effective concentration of 1.0 0 0 0, 0 .5 0 0 0,0 .2 5 0 0,0 .12 5 0,0 .0 6 2 5,0 .0 313 and 0 .0 15 7mg / L of the liquid at room temperature, respectively, at 25 ℃ Immersing snails kill experiment. Results The mortality of snail immersed 1.0mg / L for 24 hours was 10%, and the LC50 of snail was 0.032 0 ~ 0.16 89mg / L with the mean value of 0.092 mg / L. The mortality rate of 05mg / L niclosamide immersed 48h was 100%, and the LC50 of snails in each region was 0. 0299 ~ 0.1114mg / L with an average value of 0. 0627mg / L. Snail between different points on niclosamide sensitivity was significantly different (P <0. 01). Conclusion There is difference in the sensitivity of snail to niclosamide between different sites, but 1.0 mg / L niclosamide can effectively kill snail in all areas of our country.