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目的：评价血清总胆汁酸（ＴＢＡ）测定对妊娠期肝内胆汁淤积症的临床诊断价值。方法：采用酶偶联连续监测法检测妊娠期肝内胆汁淤积症、正常妊娠、非妊娠育龄女性三组的ＴＢＡ。结果：４９例妊娠期肝内胆汁淤积症，６０例正常妊娠和６０例非妊娠正常对照组的ＴＢＡ活性值差异有显著性（Ｐ＜０．０１），前者与后两组差异均有显著性（Ｐ＜０．０１）；而后两组差异无显著性（Ｐ＞０．０５）。结论：测定ＴＢＡ活性对妊娠期肝内胆汁淤积症诊断具有实用价值，可作为临床上特异性生化诊断指标之一。
Objective: To evaluate the clinical value of serum total bile acid (TBA) in the diagnosis of intrahepatic cholestasis of pregnancy. Methods: The TBA of three groups of women with intrahepatic cholestasis of pregnancy, normal pregnancy and non-pregnant women of childbearing age were detected by enzyme-linked continuous monitoring method. Results: There were significant differences in TBA activity values between 49 cases of intrahepatic cholestasis of pregnancy, 60 cases of normal pregnancy and 60 cases of non-pregnant normal control group (P <0.01). There was significant difference between the two groups (P <0.01), but there was no significant difference between the two groups (P> 0.05). Conclusion: The determination of TBA activity in the diagnosis of intrahepatic cholestasis of pregnancy has practical value, which can be used as one of the clinical biochemical indicators of specificity.