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为探讨霉酚酸酯（ＭＭＦ）加小剂量激素治疗难治性肾病综合征（ＮＳ）的疗效及副作用，并与环磷酰胺（ＣＴＸ）联用常规剂量激素进行比较。我们对１９９８年１月－２０００年３月收治的５２例难治性ＮＳ患者随机分成两组，ＭＭＦ组２４例：口服ＭＭＦ（ １．０～２．０） ｇ／ｄ加小剂量强的松（ １０～ １５） ｍｇ／ｄ， ３～ ８个月后 ＭＭＦ逐渐减量至０．５ｇ／ｄ维持；ＣＴＸ组２８例：用ＣＴＸ按８ｍｇ／ｋｇ加生理盐水５００ｍｌ静滴，每周两次，总量达１５０ｇ／ｋｇ，同时口服强的松１ｍｇ（ｋｇ·ｄ），６～８周后逐渐减量。结果提示ＭＭＦ加小剂量激素治疗难治性ＮＳ的完全缓解率、显著缓解率、部分缓解率和总有效率分别为：７５．００％、８．３３％、１２．５０％和９５．８４％，完全缓解率和总有效率均高于 ＣＴＸ加常规剂量激素治疗组（分别为 ５０．００％和 ８２． １４％）； ＭＭＦ组无效者 １例，占４．１０％，ＣＴＸ组无效者５例，占１７．８６％，经统计学方法提示，两组比较有显著性差异（Ｐ＜０．０５，且ＭＭＦ组副反应少，一年内无一例复发，ＣＴＸ组复发３例，占 １０． ７１％。
To investigate the curative effect and side effects of mycophenolate mofetil (MMF) combined with low-dose hormones in the treatment of refractory nephrotic syndrome (NS) and to compare with CTX combined with conventional dosage hormones. We treated 52 patients with refractory NS who were admitted to our hospital from January 1998 to March 2000 and were randomly divided into two groups: 24 patients in the MMF group: oral MMF (1.0-2.0) g / d plus prednisone (10 ~ 15) mg / d, 3 ~ 8 months after MMF tapering to 0.5g / d maintained; CTX group of 28 patients: CTX by 8mg / kg plus saline 500ml intravenous drip twice a week, The total amount of 150g / kg, while oral prednisone 1mg (kg · d), 6 to 8 weeks after gradual reduction. The results suggest that the complete remission rate, the significant remission rate, partial remission rate and total effective rate of MMF combined with low-dose hormone treatment of refractory NS were 75.00%, 8.33%, 12.50% and 95.84% , Complete remission rate and total effective rate were higher than CTX plus conventional dose hormone therapy group (50.00% and 82.14%, respectively); MMF group ineffective in 1 case (4.10%), CTX ineffective 5 Cases, accounting for 17.86%, the statistical methods suggest that the two groups were significantly different (P <0.05, and less side effects in MMF group, no recurrence within a year, CTX group 3 cases of recurrence, accounting for 10%. 71%.