Effects of SIRT1 Gene Knock-Out via Activation of SREBP2 Protein-Mediated PI3K/AKT Signaling on Oste

• 作 者: 于斐 曾晖 雷鸣 肖德明 李伟 袁昊 林健静
• 机 构: DepartmentofOrthopedics
• 出 处: 华中科技大学学报：医学英德文版
• 发表日期: 2016年5期
• 关键词: 信号转导通路 骨关节炎 胶原蛋白 基因敲除 小鼠 介导 HE染色 活化 cartilage Knock articular degeneration cruci
• 基金项目: This study was supported by grants from the National Natural Science Foundation of China （No. 81272032） and the Research and Development Projects of Shcnzhen of China （Nos. JCYJ20150403091443275）.

This study investigated the effects of SIRT1 gene knock-out on osteoarthritis in mice, and the possible roles of SREBP2 protein and the PI3K/AKT signaling pathway in the effects. Mice were randomly divided into a normal group and a SIRT1 gene knock-out gr