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由于β-环糊精(β-CD)对苯酚酯水解反应的催化机理与胰凝乳蛋白酶的作用机理十分相似,因此以β-CD作为模拟酶的动力学研究已经成为当前该化学领域中的一个重要课题.Breslow等报道,β-CD对2-二茂铁丙烯酸对硝基苯酚酯(1)的酰基转移反应或水解反应的催化加速程度K_c/K_(un)(k_c与k_(un)分别表示在OH~-离子浓度恒定的条件下β-CD存在及不存在时底物水解反应的速率常数)高达3.6×10~5,达到了典型的酶催化反应的数量级,因而引起了人们的广泛注意.
Since the catalytic mechanism of β-cyclodextrin (β-CD) on the hydrolysis of phenol esters is very similar to that of chymotrypsin, the kinetics of β-CD as a mimic enzyme has become the current focus in the field of chemistry An important issue.Breslow et al reported that β-CD 2-ferrocenyl acrylic acid p-nitrophenolate (1) acylation reaction or hydrolysis reaction of the degree of catalytic acceleration K_c / K_ (un) (k_c and k_ (un) Respectively indicate that the rate constant of substrate hydrolysis reaction in the presence and absence of β-CD at a constant OH ~ - ion concentration) is as high as 3.6 × 10 ~ 5, reaching the order of magnitude of typical enzyme catalysis, Wide attention.