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DL-111是一种非激素事后抗生育剂。在雄性大鼠中DL-111可使睾丸、附属性器官重量、睾丸和生殖附属腺的RNA和蛋白质浓度都降低。这些结果与阉割后生殖附属腺的变化一致。该研究评价了DL-111对睾丸透明质酸酶(一种对生精与睾丸功能敏感的生化指标)的影响。将DL-111溶于芝麻油中,以5mg/kg给雄鼠每天皮下注射共7或15天,然后做如下五个试验: (1)为了测量酶活性的发展型,在30天或6个月龄的正常雄鼠中测量睾丸的透明质酸酶活性。 (2)将21天龄的幼鼠分为4组,其中两组按
DL-111 is a non-hormonal post-anti-fertility agent. DL-111 in male rats reduced the testis, appendage organ weights, testis and reproductive glands in both RNA and protein concentrations. These results are consistent with changes in the gonadal gland after castration. This study evaluated the effect of DL-111 on testicular hyaluronidase, a biochemical indicator of spermatogenic and testicular function. The DL-111 was dissolved in sesame oil and the male mice were injected subcutaneously daily at 5 mg / kg for 7 or 15 days with the following five tests: (1) In order to measure the development of the enzyme activity, 30 days or 6 months Testis hyaluronidase activity was measured in normal male rats of age. (2) The 21-day-old pups were divided into 4 groups, of which two groups according to