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目的观察阿司匹林对人胃癌细胞株SGC7901生长及人胃癌裸鼠移植瘤生长的作用,并初步探讨其作用机制。方法采用MTT法检测不同浓度阿司匹林对胃癌细胞增殖及细胞周期的影响;建立人胃癌裸鼠移植模型,给予阿司匹林30天,观察肿瘤大小。结果阿司匹林对胃癌细胞的增殖具有抑制作用,且呈一定的时间和剂量依赖性;阿司匹林对裸鼠移植瘤的生长具有抑制作用。结论阿司匹林对胃癌细胞及裸鼠移植瘤均具有一定的抑制作用,其机制可能是通过环氧化物水解酶(COX)途径生成的相关因子抑制新生血管而起作用。
Objective To observe the effect of aspirin on the growth of human gastric cancer cell line SGC7901 and the growth of human gastric cancer xenografts in nude mice and to explore its mechanism. Methods The effects of different concentrations of aspirin on the proliferation and cell cycle of gastric cancer cells were detected by MTT assay. The model of human gastric cancer was established and treated with aspirin for 30 days to observe the tumor size. Results Aspirin could inhibit the proliferation of gastric cancer cells in a dose and time-dependent manner. Aspirin had inhibitory effect on the growth of xenografts in nude mice. Conclusion Aspirin can inhibit the growth of gastric cancer cells and xenografts in nude mice. The possible mechanism is that aspirin may inhibit angiogenesis through the related factors of epoxide hydrolase (COX) pathway.