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目的：通过肺癌转移淋巴结获取肿瘤浸润淋巴细胞（TlL），经白细胞介素－2（IL－2）等激活培养扩增后回输给病人并观察其抗肿瘤疗效。方法：对病理学证实的并伴有锁骨上淋巴结转移的肺癌17例，其中12例经放疗或化疗后效果不理想改用TIL治疗，5例单独用TIL治疗。结果：（1）同种TIL治疗可明显改善肺癌病人的一般状况，尤其能增加体力和食欲；（2）对抑制肿瘤的生长有一定的作用，可使部分肿瘤缩小甚或消失；（3）能明显改善病人的免疫状况，提高免疫指标同时也能促进血白细胞及血小板的增长。
OBJECTIVE: To obtain tumor-infiltrating lymphocytes (TlL) by metastasis of lung cancer metastases, activate them by interleukin-2 (IL-2), and then transfer them back to the patient to observe its antitumor efficacy. METHODS: Twenty-seven patients with lung cancer confirmed by pathology and associated with supraclavicular lymph node metastases were treated with TIL in 12 cases who were not treated with radiotherapy or chemotherapy. Five patients were treated with TIL alone. Results: (1) The same type of TIL treatment can significantly improve the general condition of patients with lung cancer, especially increase physical strength and appetite; (2) It has a certain effect on inhibiting the growth of tumors, and can make some tumors shrink or even disappear; (3) Significantly improve the patient’s immune status, improve immune indicators, but also can promote the growth of white blood cells and platelets.