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本文前瞻性对照观察了 IgA 肾病患者扁桃体淋巴细胞亚群、白介素-2(IL-2)、γ-干扰素(IFN-γ)及各种免疫球蛋白变化。结果表明,IgA 肾病患者扁桃体中 CD_4细胞、IL-2及 IgA 水平明显高于对照组。结果提示 IgA 肾病肉眼血尿发作与呼吸道粘膜免疫异常有关,感染可以触发或放大这种免疫反应;对于 IgA 肾病合并扁桃体炎的患者,应尽可能切除扁桃体,减少这一诱发因素。
This prospective and controlled observation of patients with IgA nephropathy tonsil lymphocyte subsets, interleukin -2 (IL-2), interferon (IFN-γ) and a variety of immunoglobulin changes. The results showed that the levels of CD 4, IL-2 and IgA in tonsil of patients with IgA nephropathy were significantly higher than those in the control group. The results suggest that gross hematuria in IgA nephropathy and respiratory mucosal abnormalities related to infection can trigger or amplify this immune response; IgA nephropathy with tonsillitis in patients with tonsillectomy should be as much as possible to reduce this predisposing factor.