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应用放免法测定妊高征患者及正常妊娠妇女血浆精氨酸加压素(AVP)及P物质(SP)浓度。结果表明,妊高征患者血浆AVP浓度较正常妊娠妇女明显增高,血浆SP浓度较正常孕妇明显降低;妊高征患者治疗后血浆AVP浓度明显降低,SP浓度明显升高;妊高征患者血浆AVP浓度与SP浓度呈负相关,正常孕妇血浆AVP浓度与SP浓度相关不显著。提示血浆AVP和SP比例失调可能是妊高征发生的重要原因之一。
The levels of plasma arginine vasopressin (AVP) and substance P (SP) in patients with PIH and normal pregnant women were measured by radioimmunoassay. The results showed that the concentration of plasma AVP in patients with PIH was significantly higher than that in normal pregnant women, and the plasma SP concentration was significantly lower than that in normal pregnant women. Plasma AVP concentration was significantly decreased and SP concentration was significantly increased after PIH treatment. Plasma AVP Concentration and SP concentration was negatively correlated, normal pregnant women plasma AVP concentration and SP concentration was not significant. Prompt plasma AVP and SP imbalance may be one of the important causes of pregnancy-induced hypertension.