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目的：探讨 Ｐ物质（ Ｓ Ｐ）在内毒素血症大鼠肠蠕动变化中的作用。方法： Ｗｉｓｔａｒ 大鼠分为对照组、内毒素血症（ Ｌ Ｐ Ｓ）组。①采用活性炭标记法观察内毒素血症状态下肠道传输速率变化；②观察内毒素血症后３、６、１２ ｈ 大鼠血浆、空肠组织匀浆 Ｓ Ｐ含量变化及空肠免疫组化 Ｓ Ｐ阳性神经在肠道分布及内毒素血症后的变化。结果：①内毒素血症后小肠传输速率加快；②内毒素血症后血浆 Ｓ Ｐ变化不显著，空肠组织 Ｓ Ｐ含量下降，空肠 Ｓ Ｐ阳性神经纤维及产物表达明显减少，且与空肠组织 Ｓ Ｐ含量变化相一致。结论：内毒素血症后肠道传输功能发生变化，可能与肠神经递质 Ｓ Ｐ改变有一定关系。
Objective: To investigate the role of substance P (S P) in the changes of intestinal peristalsis in endotoxemic rats. Methods: Wistar rats were divided into control group and endotoxemia group (L P S). (1) The changes of intestinal transit rate in the condition of endotoxemia were observed by activated carbon labeling method; (2) The changes of S P content in plasma and jejunum homogenate at 3, 6 and 12 h after endotoxemia were observed, and immunohistochemistry of P Changes of positive nerves in intestinal tract and endotoxemia. Results: (1) The rate of intestinal transit increased after endotoxemia; (2) The changes of plasma S P in endotoxemia group were not significant; the content of S P in jejunum decreased; the expression of S P positive nerve fiber and product in jejunum decreased obviously; P content changes consistent. Conclusion: The changes of intestinal transit after endotoxemia may be related to the change of intestinal neurotransmitter S P.