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目的探讨胰腺癌患者外周血抑血管生成因子血小板反应蛋白1(TSP-1)、Angiostatin及 Endostatin 的浓度改变与临床病理特点之间的关系。方法酶联免疫吸附实验测定32例胰腺癌可切除患者、24例不可切除患者和20例胰腺癌根治术后患者以及20例正常人的外周血 TSP-1、Angiostatin 及 Endostatin 浓度,分析其表达与胰腺癌患者病理分级、肿瘤大小、淋巴结转移、远处转移、血管侵犯及临床分期的关系。结果正常对照组 TSP-I、Angiostatin 及 Endostatin 浓度显著低于胰腺癌组(P<0.01);胰腺癌患者中不可切除组较可切除组 Angiostatin 及 Endostatin 表达显著升高(P<0.05);术后1周检测 Endostatin、Angiostatin 及 TSP-1显著降低(P<0.05),其中 Endostatin 及Angiostatin 差异明显(P<0.01);Endostatin 与肿瘤大小及 CA19-9表达相关;Angiostatin 与血管侵袭及肿瘤大小相关;TSP-1与血管侵袭及远处转移相关。结论抑血管生成因子与胰腺癌不同时期的血管生成密切相关。
Objective To investigate the relationship between changes of peripheral blood angiopoietin (TSP-1), Angiostatin and Endostatin in peripheral blood and clinicopathological features in patients with pancreatic cancer. Methods The levels of TSP-1, Angiostatin and Endostatin in peripheral blood of 32 patients with resectable pancreatic cancer, 24 patients with unresectable disease, 20 patients with pancreatic cancer after radical operation and 20 normal controls were measured by enzyme-linked immunosorbent assay. Pancreatic cancer patients with pathological grade, tumor size, lymph node metastasis, distant metastasis, vascular invasion and clinical stage relationship. Results The concentrations of TSP-I, Angiostatin and Endostatin in normal control group were significantly lower than those in pancreatic cancer group (P <0.01). The expression of Angiostatin and Endostatin in unresectable group was significantly higher than that in resectable group (P <0.05) Endostatin, Angostatin and TSP-1 were significantly lower in 1 week (P <0.05), and Endostatin and Angiostatin were significantly different (P <0.01); Endostatin was correlated with tumor size and CA19-9 expression; Angiostatin was correlated with vessel invasion and tumor size; TSP-1 is associated with vascular invasion and distant metastasis. Conclusions The antiangiogenic factors are closely related to angiogenesis in different stages of pancreatic cancer.