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雷尼替丁和甲氰咪胍都是H_2受体拮抗剂.甲氰咪胍可抑制肝脏混合功能氧化酶系统,从而改变药物的代谢.这种竞争性抑制可能与甲氰咪胍和细胞色素P-450的结合有关.此种抑制可以减轻某些化合物在P-450代谢后产生的毒副反应.与甲氰咪胍相比,雷尼替丁被认为与P-450结合很弱、对微粒体药物代谢几无作用.本研究旨在阐明雷尼替丁对扑热息痛肝毒性的作用特点,并研究两者相互作用的机制.作者通过动物(Fischer 344鼠)试验从SGPT改变和组织病理学表现两方面进行分析.一次经口给扑热息痛产生剂量依赖的SGPT增
Both ranitidine and cimetidine are H 2 receptor antagonists, and cimetidine inhibits the hepatic mixed-function oxidase system, thereby altering the metabolism of the drug.This competitive inhibition may be related to cimetidine and cytochrome P-450, which may reduce toxic side effects of some compounds after P-450 metabolism.Ranitidine is considered to be very weakly bound to P-450 compared to cimetidine, Microsomal drug metabolism few effect.This study aims to clarify the characteristics of ranitidine on paracetamol liver toxicity and to study the mechanism of the interaction between the two.Animals (Fischer 344 mice) test from SGPT changes and histopathology Performance Two analyzes were performed: A single oral dose of paracetamol produced a dose-dependent increase in SGPT