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例1 男,35岁。自服利福平600～800mg,服药后约10分钟、出现头晕、头痛、恶心、继而腰痛、少尿。8天来每24小时尿量<400ml,尿呈茶色。近2日频繁呕吐。2年前曾因肺结核服过利福平2～3个月。查体:Bp15.96/10.6kPa,心肺正常,肾区有叩痛。尿蛋白(++++),BUN38.6mmol/L,Scr556.9μmol/L,CO_2CP9.4mmol/L。超声双肾如常。入院后给低蛋白、高必需氨基酸饮食,防止感染,抗过敏等治疗。2天后症状渐消,尿量增多,血BUN,Scr下降。18天痊愈出院。
Example 1 male, 35 years old. Since serving rifampicin 600 ~ 800mg, about 10 minutes after taking medicine, dizziness, headache, nausea, then low back pain, oliguria. 8 days every 24 hours urine output <400ml, brown urine. Nearly 2 days vomit frequently. 2 years ago due to pulmonary tuberculosis rifampicin 2 to 3 months. Physical examination: Bp15.96 / 10.6kPa, cardiopulmonary normal, there is percussion pain in the kidney area. Urinary protein (++++), BUN38.6mmol / L, Scr556.9μmol / L, CO_2CP9.4mmol / L. Ultrasound kidneys as usual. After admission to the low-protein, high essential amino acid diet, to prevent infection, anti-allergy and other treatment. After 2 days, the symptoms disappeared, urine output increased, blood BUN, Scr decreased. 18 days cured.