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目的对糖尿病前期患者胰高血糖素样肽-1(GLP-1)及胰高血糖素的分泌特点的探讨与分析。方法对2015年1-12月河西区马场街社区卫生服务中心收治的糖尿病前期患者的一般资料进行回顾性分析探讨,并从中随机选取90例患者为研究组,选取同期健康体检人员90例作为对照组,对比两组研究对象的餐后GLP-1以及胰高血糖素等各项临床指标。结果研究组患者餐后胰岛素、GLP-1、血糖水平显著低于对照组,差异均有统计学意义(P<0.05);对照组的胰高血糖素显著低于研究组患者,差异有统计学意义(P<0.05)。结论糖尿病前期患者存在着GLP-1下降以及胰高血糖素分泌上升的问题,临床上应当引起足够的重视。
Objective To explore and analyze the characteristics of glucagon-like peptide-1 (GLP-1) and glucagon secretion in pre-diabetic patients. Methods A retrospective analysis was conducted on the general data of patients with pre-diabetes who were treated at the Community Health Service Center, Macp Street, Hexi District from January to December 2015. Ninety patients were randomly selected as the study group and 90 healthy people were selected as the control Group, comparing the two groups of subjects postprandial GLP-1 and glucagon and other clinical indicators. Results The levels of postprandial insulin, GLP-1 and blood glucose in the study group were significantly lower than those in the control group (P <0.05). The glucagon in the control group was significantly lower than that in the study group Significance (P <0.05). Conclusions The pre-diabetes patients have the problem of the decrease of GLP-1 and the increase of glucagon secretion, which should be paid more attention in clinic.