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目的 探讨周围型肺癌中CyclinD1蛋白的表达及其与CT表现的关系。方法 对 56例经手术病理证实的周围型肺癌患者的术后病理蜡块应用免疫组化SP法检测CyclinD1蛋白的表达 ,同时与术前胸部CT扫描对照。结果 CyclinD1蛋白表达率在鳞癌为 64% ( 16 2 5) ,腺癌为 67.7% ( 2 1 3 1) ,两组之间差异无显著 ;CyclinD1蛋白过表达与肿瘤分化差密切相关 (P <0 .0 1) ,在CT表现中 ,CyclinD1蛋白过表达与肿瘤直径大于 3cm、深分叶征、棘突征关系密切 (P <0 .0 5) ,与毛刺征、空泡征、空气支气管征、胸膜凹陷征、纵隔淋巴结肿大关系不显著 (P >0 .0 5)。结论 CyclinD1蛋白的过表达与周围型肺癌的发生、分化、增殖及相关的CT征象有关
Objective To investigate the expression of CyclinD1 protein in peripheral lung cancer and its relationship with CT findings. Methods The expression of CyclinD1 protein was detected by immunohistochemical SP method in 56 patients with pathologically confirmed peripheral lung cancer, and compared with preoperative chest CT scan. Results The positive rate of CyclinD1 was 64% (16 2 5) in squamous cell carcinoma and 67.7% (2 1 3 1) in adenocarcinoma. There was no significant difference between the two groups. The overexpression of CyclinD1 was closely related to the poor differentiation (P < 0 01). In CT, CyclinD1 overexpression was closely related to tumor diameter> 3 cm, deep lobulation, and spinous process (P <0.05), and was associated with burr, vacuole, air bronchus Sign, pleural indentation, mediastinal lymph node enlargement was not significant (P> 0.05). Conclusion The overexpression of CyclinD1 is associated with the occurrence, differentiation, proliferation and CT signs of peripheral lung cancer