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目的:探讨急性心肌梗死(AMI)患者血浆大内皮素(ET)、N末端脑钠肽(NT-proBNP)水平和左室室壁瘤(LVA)形成之间的关系。方法:选择确诊的AMI患者136例,LVA组68例和对照组68例,用酶联免疫吸附分析(ELISA)法测定其血浆大ET、NT-proBNP,部分患者均行超声心动图检查测定左室舒张末内径、左室射血分数(LVEF)及室壁运动指数(WMSI),并行左室造影检查测定左室收缩末期容积和左室舒张末期容积,LVEF及左室室壁运动记分。结果:LVA组的血浆大ET、NT-proBNP水平(1.32±1.24)pmol/L、(1 871.08±1304.63)pmol/L显著高于对照组,差异有统计学意义(P<0.01);LVA的患者较对照组左室扩大及LVEF减低更为明显,差异具有统计学意义(P<0.01)。结论:血浆大ET、NT-proBNP水平增高与AMI后LVA形成可能相关。
Objective: To investigate the relationship between plasma endothelin (ET), NT-proBNP level and the formation of left ventricular aneurysm (LVA) in patients with acute myocardial infarction (AMI). Methods: 136 patients with confirmed AMI, 68 patients with LVA and 68 patients with control group were enrolled in this study. Plasma ET and NT-proBNP were measured by enzyme-linked immunosorbent assay (ELISA), and some patients underwent echocardiography The left ventricular end-diastolic diameter, left ventricular ejection fraction (LVEF) and wall motion index (WMSI) were measured. Left ventricular end-systolic volume, left ventricular end-diastolic volume, LVEF and left ventricular wall motion score were determined by parallel left ventricular angiography. Results: The levels of plasma ET and NT-proBNP in LVA group were significantly higher than those in control group (1.32 ± 1.24 pmol / L, (1871.08 ± 1304.63) pmol / L, P <0.01) Patients than the control group, left ventricular enlargement and LVEF decreased more significantly, the difference was statistically significant (P <0.01). Conclusion: The increase of plasma ET and NT-proBNP may be related to the formation of LVA after AMI.