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研究1-乙酰基佛司可林（1-aF）混悬滴眼液对清醒兔及人眼内压（IOP）的影响及相关副作用．将1-aF配制成1%混悬滴眼液，一侧眼滴1-aF，另一侧眼滴溶媒对照，用气动式非接触眼压计测IOP，并观察药物的副作用．结果：1%1-aF滴眼液滴眼给药后，显著降低兔IOP，最大至0.29?kPa，作用持续约3?h；但对自愿受试者给药后，其作用不明显．1-aF 对兔及人基本没有眼局部刺激反应．结果表明：1-aF能降低正常兔IOP，但对正常人IOP作用不明显，基本没有眼局部刺激反应．“,”To investigate effects of l% l-acetylforskoin (l-aF) suspension eye-drops administeredtopically on intraocular pressure (IOP) in rabbits and men, and observe the loca l irritation of the drug． l% l-aF suspension eye-drops was prepared and was instilled into one of e yes while the corresponding vehicle into the contralateral eye as control． IOP was measured b y pneumatonometer before and after administration． l%1-aF suspension eye-drops s ig nificantly reduced IOP in rabbits reaching the maximum reduction of 2.2 mmHg and lasting a t least 3 hours． But it didnt show significant effects in men． There was little local irritati on neither in rabbits nor in men． l% l-aF suspension eye-drops significantly reduced IOP in normal rabbit s, but not in men． No local irritation was observed in rabbits and in men．