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为比较氟哌酸(norfloxacin)和环丙氟哌酸(悉复欢、环丙沙星、ciprofloxacin)预防恶性血液病伴中性粒细胞减少患者细菌感染的效果,作者随机选择801名急性白血病或其它血液病成人住院患者。这些患者均伴有中性粒细胞减少(<1000/mm~3),且持续10天以上。从给予化疗前1—3天开始观察,将患者随机分为二组。一组每12小时口服氟哌酸400mg,另一组每12小时口服环丙氟哌酸500mg。当中性粒细胞>1000mm~3时停止预防性治疗。部分病例还应用了抗真菌或抗病毒预防治疗及中心静脉插管。未应用中性粒细胞输注。801例中有182例因种种原因不能作有效性分析。余619例中319例以氟哌酸治疗,300例
To compare the efficacy of norfloxacin and ciprofloxacin in the prevention of bacterial infections in patients with hematologic malignancies associated with neutropenia, we randomly selected 801 acute leukemias or Other blood diseases Adult hospitalized patients. All of these patients had neutropenia (<1000 / mm ~ 3) for more than 10 days. One to three days before chemotherapy, the patients were randomly divided into two groups. One group received 400 mg of norfloxacin every 12 hours and the other group received 500 mg of ciprofloxacin every 12 hours. When neutrophils> 1000mm ~ 3 to stop prophylactic treatment. Some cases also applied anti-fungal or anti-viral prophylaxis and central venous catheterization. No neutrophil infusion was applied. 182 of 801 cases can not be validated for various reasons. Of the remaining 619 cases, 319 were treated with norfloxacin, 300