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目的通过监测钙通道阻滞剂尼莫地平干预下,新生儿缺氧缺血性脑病(HIE)患儿血清钙、NO及IL-18的变化,观察尼莫地平对HIE患儿病情缓解的积极作用,说明尼莫地平在治疗HIE中具有很好的应用前景及临床价值。方法将尼莫地平治疗组、常规治疗组、对照组分别于生后1d、3d、7d、14d检测血清钙、NO、IL-18。结果 HIE患儿生后第1天Ca2+含量较对照组降低,血清NO及IL-18含量较对照组均有升高,对比有统计学意义(P<0.01);且中、重度HIE患儿Ca2+含量低于轻度HIE患儿,血清NO及IL-18含量明显高于轻度HIE患儿,对比有统计学意义(P<0.01);经尼莫地平治疗的HIE患儿生后血清Ca2+、NO及IL-18含量恢复正常时间明显早于常规治疗组,对比有统计学意义(P<0.01)。结论血清Ca2+、NO及IL-18含量与病情的严重程度相关,可以作为HIE病情变化的监测指标;尼莫地平可降低HIE所致的脑细胞损伤,提高对HIE的治疗疗效。
Objective To investigate the changes of serum calcium, nitric oxide and interleukin-18 in children with hypoxic-ischemic encephalopathy (HIE) under the intervention of calcium channel blocker nimodipine and to observe the positive effect of nimodipine on the remission of HIE Role, indicating that nimodipine in the treatment of HIE has good application prospects and clinical value. Methods The levels of serum calcium, NO and IL-18 in nimodipine treatment group, routine treatment group and control group were detected on the 1st, 3rd, 7th and 14th day after birth respectively. Results The content of Ca2 + on the first day after birth in HIE children was lower than that in the control group, and the levels of serum NO and IL-18 in the HIE children were higher than those in the control group (P <0.01) The levels of serum NO and IL-18 in children with HIE were significantly lower than those in mild HIE (P <0.01); the serum levels of Ca2 + NO and IL-18 levels returned to normal earlier than conventional treatment group, the difference was statistically significant (P <0.01). Conclusions Serum levels of Ca2 +, NO and IL-18 correlate with the severity of the disease, which may be used as a monitoring indicator for the progression of HIE. Nimodipine can reduce the injury of brain cells induced by HIE and improve the therapeutic effect on HIE.