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目的探讨老年男性缺血性脑卒中患者炎性因子血清学水平变化与预后的关系。方法选取2012年1月—2014年1月收治的54例老年男性缺血性脑卒中患者为观察组,并选取同期体检的老年男性健康志愿者54例为对照组。对观察组患者在发病第1、3、7、14、30d的血清雌激素(E2)、高敏C反应蛋白(hs-CRP)、白介素6(IL-6)水平以及NIHSS评分的变化与对照组进行比较,分析各观察指标的变化及与预后的关系。结果观察组患者IL-6、hs-CRP水平高于对照组,E2水平低于对照组,具有统计学意义(P<0.05)。IL-6与白细胞计数、NIHSS评分、GCS评分有相关性。E2与白细胞计数、NIHSS评分、GCS评分有相关性。hs-CRP与白细胞计数、低密度脂蛋白、三酰甘油、高密度脂蛋白、NIHSS评分、GCS评分有相关性。IL-6、E2、hs-CRP分别与NIHSS评分有相关性。结论 E2对男性缺血性脑卒中的恢复有积极的意义,IL-6、hs-CRP在缺血性脑卒中急性期有不利影响。IL-6、E2、hs-CRP的血清变化水平可以作为反映患者病情变化的有意义的临床指标。
Objective To investigate the relationship between serum inflammatory cytokines and prognosis in elderly male patients with ischemic stroke. Methods Fifty-four elderly male ischemic stroke patients admitted from January 2012 to January 2014 were selected as the observation group. 54 healthy elderly volunteers were selected as the control group. The change of serum estradiol (E2), high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6) and NIHSS scores in the observation group on the 1st, 3rd, To compare and analyze the changes of each observation index and the relationship with prognosis. Results The levels of IL-6 and hs-CRP in the observation group were higher than those in the control group, and the E2 level was lower than that in the control group (P <0.05). IL-6 was correlated with white blood cell count, NIHSS score and GCS score. E2 and white blood cell count, NIHSS score, GCS score correlation. hs-CRP was correlated with white blood cell count, low density lipoprotein, triglyceride, high density lipoprotein, NIHSS score and GCS score. IL-6, E2, hs-CRP were correlated with NIHSS score respectively. Conclusions E2 has a positive effect on the recovery of ischemic stroke in men. IL-6 and hs-CRP have an adverse effect on the acute stage of ischemic stroke. Serum levels of IL-6, E2, hs-CRP can be used as a meaningful clinical indicator of the patient’s condition.